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Molecular network-based intervention brings us closer to ending the HIV pandemic

Xiaoxu Han, Bin Zhao, Minghui An, Ping Zhong, Hong Shang

Frontiers of Medicine 2020, Volume 14, Issue 2,   Pages 136-148 doi: 10.1007/s11684-020-0756-y

Abstract: populations, reconstruct the history of HIV spread, monitor the dynamics of HIV transmission, guide targetedintervention on key subpopulations, and assess the effects of interventions.

Keywords： human immunodeficiency virus type 1     molecular cluster     transmission cluster     risk network     targeted intervention    

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The early percutaneous coronary intervention in elderly patients with acute coronary syndrome

HUANG Xiong, CAO Xuebin, ZHANG Gang

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 15-18 doi: 10.1007/s11684-008-0004-3

Abstract: It is challenging to undo early percutaneous intervention (PCI) in the elderly with acute coronary syndromeAll the patients had early percutaneous coronary intervention and were followed up for 6–12 months by

Keywords： door-to-balloon     percutaneous intervention     coronary syndrome     angioplasty     successful    

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Ultrasound-guided prostate percutaneous intervention robot system and calibration by informative particle

Frontiers of Mechanical Engineering 2022, Volume 17, Issue 1,   Pages 3-3 doi: 10.1007/s11465-021-0659-x

Abstract: Applying a robot system in ultrasound-guided percutaneous intervention is an effective approach for prostate

Keywords： ultrasound image guidance     prostate percutaneous intervention     parallel robot     kinematics identification    

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Drug-coated balloon-only strategy for percutaneous coronary intervention of left main coronary artery

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 75-84 doi: 10.1007/s11684-022-0950-1

Abstract: single-center registry study included all consecutive patients who underwent percutaneous coronary intervention

Keywords： drug-coated balloon     left main     high bleeding risk     predilatation     calcifield lesion     percutaneous coronary intervention    

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Molecular markers and pathogenically targeted therapy in non-small cell lung cancer

Bo PENG BA , Jinnong ZHANG MD , Jamile S. WOODS MD , Wei PENG MD, PhD

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 245-255 doi: 10.1007/s11684-009-0044-3

Abstract: Therefore, this information may be applied for early cancer detection, classification, novel targetedRecent clinical data have revealed that targeted therapy might be the second-line therapy as an alternativeCurrently, the targeted therapies are mainly focused on two lung cancer pathways, the EGFR and the vascularTherefore, it is very important to select NSCLC patients with biomarkers to match targeted agents sothat we can further identify effectiveness of targeted therapy in the future.

Keywords： lung cancer     carcinoma     non-small cell lung cancer     molecular markers     targeted therapy    

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Expression of integrin in hepatic fibrosis and intervention of resveratrol

Jianye WU, Chuanyong GUO, Jun LIU, Xuanfu XUAN

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 100-107 doi: 10.1007/s11684-009-0013-x

Abstract: this study was to explore the expression of integrin-β1 in different stages of hepatic fibrosis and intervention

Keywords： liver fibrosis     integrin-β1     resveratrol     tumor growth factor-β     tissue inhibitor of metalloproteinase-1    

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Dietary Lipid Intervention in the Prevention of Brain Aging

Wei Xiong,Bing Fang,Xiaoyu Wang,Ming Zhang,Min Du,Jiazeng Sun,Juan Chen,Yixuan Li,Changhao Sun,Xingen Lei,Xue Zhang,Fazheng Ren,

Engineering doi: 10.1016/j.eng.2023.04.012

Abstract: As people live longer, the burden of aging-related brain diseases, especially dementia, is increasing. Brain aging increases the risk of cognitive impairment, which manifests as a progressive loss of neuron function caused by the impairment of synaptic plasticity via disrupting lipid homeostasis. Therefore, supplemental dietary lipids have the potential to prevent brain aging. This review summarizes the important roles of dietary lipids in brain function from both structure and mechanism perspectives. Epidemiological and animal studies have provided evidence of the functions of polyunsaturated fatty acids (PUFAs) in brain health. The results of interventions indicate that phospholipids—including phosphatidylcholine, phosphatidylserine, and plasmalogen—are efficient in alleviating cognitive impairment during aging, with plasmalogen exhibiting higher efficacy than phosphatidylserine. Plasmalogen is a recognized nutrient used in clinical trials due to its special vinyl ether bonds and abundance in the postsynaptic membrane of neurons. Future research should determine the dose-dependent effects of plasmalogen in alleviating brain-aging diseases and should develop extraction and storage procedures for its clinical application.

Keywords： Brain aging     Nutritional intervention     Phospholipids     Phosphatidylcholine     Phosphatidylserine     Plasmalogen    

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Influence of Survivin-targeted siRNA on the biological features of colorectal carcinoma cells

XIONG Ying, GUO Wen, LI Ting, LI Ke

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 304-307 doi: 10.1007/s11684-007-0058-7

Abstract: The transient transfection of survivin-targeted siRNA to Lovo cells and its influence on the biologicalTwo pairs of 19 base pairs (bp) siRNA-specific targeted survivin gene were designed and synthesized byAfter transient transfection of the two survivin-targeted siRNAs to Lovo cells by Lipofectamine™ 2000Based on the results, we can draw a conclusion that the two survivin-targeted siRNAs successfully suppressed

Keywords： control     therapy     influence     Survivin-1     colorectal carcinoma    

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A Double-Layer Polysaccharide Hydrogel (DPH) for the Enhanced Intestine-Targeted Oral Delivery of Probiotics

Wen-Can Huang,Wenjie Wang,Wei Wang,Yanan Hao,Changhu Xue,Xiangzhao Mao,

Engineering doi: 10.1016/j.eng.2023.05.024

Abstract: This double-layer structure allows DPH to encapsulate and deliver probiotics in a targeted manner withinThus, DPH endows probiotics with excellent intestine-targeted delivery, improved oral bioavailability

Keywords： Polysaccharides     Chitosan     Hydrogels     Oral delivery     Intestine-targeted    

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Micro-Intervention Rural Planning Based on Cultural Heritance

Guo Haian

Strategic Study of CAE 2019, Volume 21, Issue 2,   Pages 27-33 doi: 10.15302/J-SSCAE-2019.02.019

Abstract: The micro-intervention planning theory is a cultural-guided planning strategy for rural revival, where

Keywords： rural planning     micro-intervention planning     consequential     fault-tolerant     rural culture     rural revival    

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Progress and challenges in RET-targeted cancer therapy

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 207-219 doi: 10.1007/s11684-023-0985-y

Abstract: The rearranged during transfection (RET) is a receptor protein tyrosine kinase. Oncogenic RET fusions or mutations are found most often in non-small cell lung cancer (NSCLC) and in thyroid cancer, but also increasingly in various types of cancers at low rates. In the last few years, two potent and selective RET protein tyrosine kinase inhibitors (TKIs), pralsetinib (BLU-667) and selpercatinib (LOXO-292, LY3527723) were developed and received regulatory approval. Although pralsetinib and selpercatinib gave high overall response rates (ORRs), < 10% of patients achieved a complete response (CR). The RET TKI-tolerated residual tumors inevitably develop resistance by secondary target mutations, acquired alternative oncogenes, or MET amplification. RET G810 mutations located at the kinase solvent front site were identified as the major on-target mechanism of acquired resistance to both selpercatinib and pralsetinib. Several next-generation of RET TKIs capable of inhibiting the selpercatinib/pralsetinib-resistant RET mutants have progressed to clinical trials. However, it is likely that new TKI-adapted RET mutations will emerge to cause resistance to these next-generation of RET TKIs. Solving the problem requires a better understanding of the multiple mechanisms that support the RET TKI-tolerated persisters to identify a converging point of vulnerability to devise an effective co-treatment to eliminate the residual tumors.

Keywords： pralsetinib     selpercatinib     RET-alteration     lung cancer     thyroid cancer     tumor-agnostic therapy     drug resistance    

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Molecular classification and molecular targeted therapy of cancer

Miao Xu, Jianyong Shao, Yixin Zeng

Frontiers of Medicine 2013, Volume 7, Issue 2,   Pages 147-149 doi: 10.1007/s11684-013-0274-2

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Microwave-induced high-energy sites and targeted energy transition promising for efficient energy deployment

Frontiers in Energy 2022, Volume 16, Issue 6,   Pages 931-942 doi: 10.1007/s11708-021-0771-y

Abstract: In this study, a high-energy-site phenomenon and targeted-energy transition mechanism were identifiedThe whole process, including microwave energy concentration and intense site-energy release, shapes a targeted-energyThe microwave-induced high-energy sites and targeted energy transition provide an important pathway for

Keywords： microwave discharge     high-energy sites     targeted-energy transition     morphology design     energy efficiency    

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Synthesis and application of superparamagnetic iron oxide nanoparticles in targeted therapy and imaging

Liangqian Tong, Ming Zhao, Shu Zhu, Jing Chen

Frontiers of Medicine 2011, Volume 5, Issue 4,   Pages 379-387 doi: 10.1007/s11684-011-0162-6

Abstract: studies have shown the exciting potential of functionalized SPIO nanoparticles, such as surface-coated, targetedligand-conjugated, and/or drug-loaded SPIO nanoparticles, as powerful tools for targeted imaging andprimarily concentrate on the recent advancements in the field of SPIO nanoparticles in terms of synthesis, targeted

Keywords： nanoparticles     superparamagnetic iron oxide     targeted therapy     molecular imaging     cancer    

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Potential unreliability of ALK variant allele frequency in the efficacy prediction of targeted therapy

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 493-502 doi: 10.1007/s11684-022-0946-x

Abstract: heterogeneity (ITH) has been proven to contribute to the poor treatment response and the resistance to targetedwhether the variant allele frequencies (VAFs) of ALK fusions can help assess ITH and predict targetedALK VAF determined by hybrid capture-based NGS is probably unreliable for ITH assessment and targeted

Keywords： situ hybridization     immunohistochemistry     variant allele frequency     intratumoral heterogeneity     targeted    

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Title Author Date Type Operation

Molecular network-based intervention brings us closer to ending the HIV pandemic

Xiaoxu Han, Bin Zhao, Minghui An, Ping Zhong, Hong Shang

Journal Article

The early percutaneous coronary intervention in elderly patients with acute coronary syndrome

HUANG Xiong, CAO Xuebin, ZHANG Gang

Journal Article

Ultrasound-guided prostate percutaneous intervention robot system and calibration by informative particle

Journal Article

Drug-coated balloon-only strategy for percutaneous coronary intervention of left main coronary artery

Journal Article

Molecular markers and pathogenically targeted therapy in non-small cell lung cancer

Bo PENG BA , Jinnong ZHANG MD , Jamile S. WOODS MD , Wei PENG MD, PhD

Journal Article

Expression of integrin in hepatic fibrosis and intervention of resveratrol

Jianye WU, Chuanyong GUO, Jun LIU, Xuanfu XUAN

Journal Article

Dietary Lipid Intervention in the Prevention of Brain Aging

Wei Xiong,Bing Fang,Xiaoyu Wang,Ming Zhang,Min Du,Jiazeng Sun,Juan Chen,Yixuan Li,Changhao Sun,Xingen Lei,Xue Zhang,Fazheng Ren,

Journal Article

Influence of Survivin-targeted siRNA on the biological features of colorectal carcinoma cells

XIONG Ying, GUO Wen, LI Ting, LI Ke

Journal Article

A Double-Layer Polysaccharide Hydrogel (DPH) for the Enhanced Intestine-Targeted Oral Delivery of Probiotics

Wen-Can Huang,Wenjie Wang,Wei Wang,Yanan Hao,Changhu Xue,Xiangzhao Mao,

Journal Article

Micro-Intervention Rural Planning Based on Cultural Heritance

Guo Haian

Journal Article

Progress and challenges in RET-targeted cancer therapy

Journal Article

Molecular classification and molecular targeted therapy of cancer

Miao Xu, Jianyong Shao, Yixin Zeng

Journal Article

Microwave-induced high-energy sites and targeted energy transition promising for efficient energy deployment

Journal Article

Synthesis and application of superparamagnetic iron oxide nanoparticles in targeted therapy and imaging

Liangqian Tong, Ming Zhao, Shu Zhu, Jing Chen

Journal Article

Potential unreliability of ALK variant allele frequency in the efficacy prediction of targeted therapy

Journal Article